ԤˤʤΤϡѤǤ

شϢ˥塼

ݤΰŷ˥塼(TV)/ͭ̾ͤξ㽸ΰ

γ

ǥŤγԤäƤݥȥˡå

ܤǥΤ˶ϫ򤷤Ƥ륳ȥˡåȥǥåɡåȤܻҤ뤳ȤƤƤȤ

WENNˤȡȥˡ39Ф̼лƤ뤬λγǥȤΤȡ2ܤۤȻפäƤϤʤ⡢ҺǥǤ֤ʤȥǥåɤϸ롣ֻҺϻ֤ܻҤͤƤ衣Һι԰٤繥ɡѤʤäפȡǥåɤϥȤƤ롣

ȥˡϲή򷫤֤2004ǯ1ǥȯɽγʤлͤϸꡢΰҤäҶߤ餢ʤǤäܻұȤ͡פȸäƤ
(ȥˡåȥǥåɡåȡܻҤƤ)

ǥɤȤ


ǥ(WHOˤ)ϡǥʤ2ǯǥ˻ʤ֡פȤʤäƤޤǥ˻ʤ֤ȯǥٰʾǥʬڸǥ˻ʤ֤³ȯǥȶ̤⤢ޤ

ǥʬȤƤϡǥǥξ˸ʣǥꡢ줾줪褽1/3٤ȤƤޤ

ǥȤƤϡ㳲ǥ̲㳲ɺӤpickup㳲ʤɡˡҵǥ(ڼھɡȯʤ)ҡǴŬ(ȱְҤޤ)ҵɤʤɤޤ

ǥȤƤϡ˳̵Ҿɡ̵ҾɡҾɡ㳲ʤɤޤ

ǥɤθȤƤϡʤдβ¬ꡢĶȸҵܴ⸡ǡɸ(ߥʤ)ΤۤмŬڤʻʬ縡(ҵ¤Ƥʤ)ҵտǤʤɤԤޤ

¾ˤ⡢ɬפ˱ʢжMRIʤɤβʹθʤɤԤޤʤСոԤޤ

Ǹꤵ줿硢μŤԤȤˤʤޤθԤäƤ⡢Ǥʤǥ10¸ߤƤޤ

ǥŤȤ


ǥŤϡޤˤȡǥŤȹ(͹γ)ʬޤǥŤˤϡߥˡ䥯ߥåˡhMG-hCGFSC-HCGˡޤޤޤ

ȥˡåϡγԤäƤääǤγ(IVF;In Vitro Fertilization)ȤϡǥŤΰĤǡ̾ǹԤΤγǹԤˡǤʬˤҵ˰ܿ뤳Ȥޤγܿ(IVF-ET)Ȥޤ

͹Ȥϡ˹碌ƽҤ뼣ŤǤʬ¸Τν䡢ưɹҤǻ̤Ԥ뤳Ȥˤʤޤ

ŪγήϡʲΤ褦ʤΤǤ³ɤ

γ徲ݥ꡼̡ǥ󤵤

2001ǯ뤷Ƥ2ܤǥƤȺǯ8ȯɽ꡼̡ǥ󤬡ߡʢ֤ϤʤȲ²طԤ󥿥ӥ塼Ǹä

WENNˤȡ֥꡼̤ȥ͡ʥ󥸥ˤ֤ȤФäƤޤߤǥƤޤפȲ²طԤ󡦥å˸äȤ꡼̤ǥϥݡޥˤäȯɽ줿ΤäƻФƤϥȤФƤʤ꡼̤γ2001ǯ©ҤΥ͡㡼륺лƤ롣

꡼̤ץͤ⥸㡼ʥ롦ɡȥꥪˡʤǥƤʤȤäƤ롣ˤȡ徲ȻפäƤǰʤʤäȥȡֿ˥äȤΤꡢͤȤȤƤ⥷åޤפȸꡢߤγǤǥߤƤȸäƤ롣
(ή2ܤǥȯɽ꡼̡ǥ󡢸ߤǥƤʤȲ²)

γȤ


γ(IVF;In Vitro Fertilization)ȤϡǥŤΰĤǡ̾ǹԤΤγǹԤˡǤʬˤҵ˰ܿ뤳Ȥޤγܿ(IVF-ET)Ȥޤ

͹Ȥϡ˹碌ƽҤ뼣ŤǤʬ¸Τν䡢ưɹҤǻ̤Ԥ뤳Ȥˤʤޤ

γή


γήȤƤϡҤμ褷()γҤȼ()ܤҵܹФᤷޤ(ܿ)

ŪˤϡޤʣҤμ褹뤿ᡢʥɥȥԥGnRH˥ȤĤFSH/hMGޤˤ˦ȯ¥ޤ(ץ쥭奢ɡդ䡢塼ץʤ)˦¤18mmã顢FSH/hMGޤλLHѤȤʤhCGޤͿϤ¥ޤ

hCGͿ3436ָˡԤޤɽޤ̮ΤȷĶȥɲ˦ɤ˦դȤȤҤ۰ޤ

Ҥ24ܤ塢ǽưǻ٤10/mL٤ˤʤ褦ͷդäޤǤϡ2ʬãФICSI(˦ˡ)Ԥޤ

ICSI(˦ˡ)ȤϡҤư٤饹ɤ館ƥۡǥ󥰥ԥڥåȤĻκ˦1ĤҤˡǤ¾θˡӤˡϼΨ⤯Ѥ褦ʤäƤޤ

ˡʲΤ褦³ޤ³ɤ

ʤɤξ㽸ݥŷ˥塼

ʲϡŷ˥塼Ϥξ򰷤äΤ򵭤Ƥޤ
ŷ˥塼פƤ򡢰Ūʲ򤨤ƾҲ𤷤Ƥޤ

ʰ䡢աʬʤɡºݤˤäƹʬ䤹ƤޤؽʿĤ⡢ȤκƸVTRʤɤǡääٶȤ˻Ĥ䤹Ȥ⤢Ȼפޤ(ˡ緶ˤƤ̤ݤޤ)

2009.05.06յ
ʲΤ褦ˡ줾ηǺܷȤʬष¤٤ޤˤۤɡǺǯʤäƤޤ

2009.09.09յ
֥ŷ˥塼פηǺƤϡʲΥڡʬޤ

³ɤ

ߥȥɥꥢ¤DNAγִǽˡ

¡֥ߥȥɥꥢ¡פθȤʤ۾ߥȥɥꥢDNAҤʳǰʤ褦֤뵻Ѥƥ쥴򹯲ʳʤɤθबȯεѤȤäƥλҤɤ뤳Ȥ5000ͤ1ͤȸƱɻߤˤĤʤǽȤ26Ѳʳػ֥ͥ㡼(Ż)ȯɽ

ʪΰ󤬽񤭹ޤ줿DNAϡΤȤƺ˦γˤ¸ߤƤ롣˳κ˦ˤ뾮ﴱ֥ߥȥɥꥢפˤDNAꡢΰ۾郎¡Ǿʤɤεǽ㳲

ϡߥȥɥꥢ¤§Ȥƽ뤳ȤܡϤҤ顢ˤΤ߹¿ΡפФ̤Υ᥹Ҥ¿ΤȴΤͻ礵

Ҥƻҵܤ˰̡ܿ4лҤθ2ɤޤ줿4ɤȤ򹯤ǡΥ᥹ΥߥȥɥꥢDNAϼѤǤʤä

Ʊ祪쥴ĹฦΩÿθϡֿͤ˱Ѥˤϡ軰Ԥ󶡤ɬפˤʤʤɲ꤬뤬衢ߥȥɥꥢ¤ΰɻߤĤȤʤǽפä
([ߥȥɥꥢ]ҤʳǣģΣִƸ)

ߥȥɥꥢ¤Ȥ


ߥȥɥꥢ¤ȤϡߥȥɥꥢDNAñ줪ʣη缺Ѱۤˤߥȥɥꥢεǽ㳲Ū֤Ȥ뤵ޤޤʼǤ

⤽⡢ߥȥɥꥢϡͥ륮˦⾮ﴱǤΥߥȥɥꥢ˰۾򤭤ȡ̤Υͥ륮ɬפȤʶڡзϤˤޤ۾򤭤ޤڤ⤷Фп졢İǢ¡վ㳲ʤɤιʻɤ٤ˤߤޤ

ߥȥɥꥢ¤6070ϡ3·°ޤ3·Ȥϡ
1)ʹɸ(CPEO)
2)myoclonus epilepsy associated with ragged-red fibers(MERRFragged-red fibersȼߥ̥)
3)mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes(MELASǾ´ȯɤȼߥȥɥꥢߥѥ)
ؤޤߥȥɥꥢDNAΰ۾Ѱ̡ˤΰ㤤ˤꡢȯɤϾ嵭3ʬޤ3·ʳǤLeigh(꡼)ǾɤǤ¿𤵤Ƥޤ

3˶̤Ƥɾϡ㲼Ȥʤ餫оɾĹǤʹɸ(CPEO)Ǥϡ۲⡢MERRFǤϾǾĴߥ̥ڻMELASǤ´;ɾ(ȯƬˡ)ڻʤΩ㲼½ˤϷ١ǧʤȤ¿Ǥ

ߥȥɥꥢ3·ο


ʹɸ(CPEO)ǤȯɤϾͤޤǤ1020Ф˵Ť뤳ȤǤ¿Ǥޤ۲(ޤ֤뤳)ǵŤ졢ؤδ屿ư¤ޤ

ɾΤߤΤΤ⤢ޤȾϰϫͻζ㲼ȼޤɾ쿧Ƴ㳲ȼΤKearns-Sayre(-)ɸ(KSS)ȸƤФƤޤ

ȤƤϡաͤξ徺繱ξ徺ֿܤݤ¸ߤγǧȥcǹdz»ݤ뤳(ʬ»)ǡǤꤷޤʶmtDNAˤѰۤߤޤդʬΥDNAˤѰۤϤߤޤ

myoclonus epilepsy associated with ragged-red fibers(MERRF[ޡ]ragged-red fibersȼߥ̥)ϡȯɤϾͤޤǤǤ¿Ͼ˥ߥ̥ǾĴǵŤޤȯζľǤвȤȤˤ󡢶㲼ŪԤʹԤޤ40δԤ˿ھɤʻȤƤޤ

ǤϷաä˿դͤξ徺ߤޤǤֿܤݡȥcʬ»SSV(strongly SDH-reactive blood vesselư̮ʿں˦˰۾ߥȥɥꥢäƤ)ʤɤ80ʾδԤǤߤޤ³ɤ
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